“Magic mushroom.” A mushroom that does magic, and capable of selling out any magic show. Who wouldn’t want to see a mushroom do some tricks to the audience? Sounds interesting, right?

Sorry to disappoint you all at the very beginning of this article, but the magic mushroom does not indicate a mushroom that does magic. There is a chemical known in the industry 4 Aco DMT is known as “Magic Mushroom.”

4-Aco-DMT is a psychoactive drug. This drug changes many activities in the brain, alter perceptions, changes moods, and behaviors.  The Use of this drug is now slowly becoming popular as a replacement for other psychoactive drugs.

History of 4-AcO-DMT

Albert Hoffman and his partner Franz Troxler were working together at Sandoz laboratories in Switzerland. While working there, they were trying to find a psychoactive prodrug. After many difficulties in January of 1963, they were able to synthesize 4-AcO-DMT successfully.

The drug goes by other names as well, such as O-Acetylpsilocin, Psilocin, 4-acetoxy-DMT. After the invention, it was not introduced in the market. It took around 27 years for Sandoz laboratories to sell this drug in the market.  This drug is marketed as a “research chemical” or “designer drug.”

What is 4 AcO DMT?

There are certain classes of mushrooms. One of the ones is known as psychedelic mushrooms. Psychedelic mushrooms contain a chemical known as Psilocin and also known as 4-HO-DMT, 4-hydroxy DMT. This structure is the base structure for 4-AcO-DMT.

4 aco dmt structure

Adding of acetyl functional group is the reaction known as acetylation. Psilocin under acetylation creates 4-AcO-DMT. This structure is a semisynthetic compound because the whole structure is not designed. The change includes only the addition of a part of the functional group.

4-AcO-DMT is a prodrug of Psilocin. Compared to Psilocin, the semisynthetic product shows more resistance to oxidation reaction under alkaline conditions. This resistance is because of the acetoxy group embedded in them.

Another analog of Psilocin is Psilocybin. But 4-AcO-DMT more popular than Psilocybin. The reason behind the popularity is the easy preparation method. Although almost both the products show the same mechanism of action but relatively easy preparation is the reason why 4-AcO-DMT is preferred.

What is 4-AcO-DMT fumarate?

In recent times there has been a rise in the study of drugs, which are psychedelic agents. Psychedelic agents are drugs that have the potentiality for the treatment of mood disorders.

Psilocin is not administered, another chemically modified version is created. 4-acetoxy-N, N-dimethyltryptamine, commonly 4-AcO-DMT, or Psilacetin is prepared in laboratories by using acylation reaction. This product is a prodrug of Psilocin.

The metabolic compound creates hallucinating effects.  This is also commonly known as “magic mushroom” effects. In 1999 the compound was converted into salt fumarate. Then the structure is 4-acetoxy-N.N-dimethyltryptamine fumarate.

4-AcO-DMT dosage and therapeutic Use

The primary Use of 4-AcO-DMT is in clinical research, is a prodrug of Psilocin. There are some therapeutic purposes for what 4-AcO-DMT was used. A hypothesis was roaming around stating 5-HT2A agonists are responsible for alleviating withdrawal symptoms and also have the ability to prevent addiction from even occurring.

The experiment was conducted on mice where the animals are first made dependent on an opiate. The 4 AcO DMT is given to the mice. The single-dose stops the nicotinic exposure and blocks the nicotine-dependent sate.

But it is still unclear how we can apply this effect to humans. Another consequence is the treatment of depression. Even microdose shows a significant impact on the animals.  There are reports of lifting the mood and emotional stability of the depressed or anxious individuals.  So different dangerous and addictive pharmaceuticals are used to warn off.

This drug is sold as fumarate salt. There are different dosages marketed. On an average 1mg pure 4-AcO-DMT powder is found in 1.24mg of powder. These powder are for oral administration.  The method of taking this powder is by snorting.

Oral 4-AcO-DMT dosage

•    Threshold: 2.5 – 5mg

•    Light: 5 – 10mg

•    Common: 10 – 25mg

•    Strong: 25 – 40mg

•    Heavy: 40+mg

Intranasal 4-AcO-DMT dosage

•    Threshold: <5

•    Light: 5 – 10

•    Common: 10 – 20

•    Strong: 20 – 30

•    Heavy: 30+


•    Onset: 10 – 45 min

•    Come-up: 30 min – 2 hr

•    Plateau/peak: 2 – 3 hr

•    Come-down: 1 – 2 hr

•    Total duration: 3 – 8 hr


•    Onset: 5 – 25 min

•    Come-up: 30 – 60 min

•    Plateau/peak: 1 – 3 hr

•    Come-down: 45 min – 1.5 hr

 •    Total duration: 2 – 6 hr

Effect of 4-AcO-DMT dosage

A variety of effects are reported on administering 4-AcO-DMT. Some results are listed below:

  • Euphoria
  • Laughter
  • Mental/physical stimulation
  • Improvement in vision
  • Appreciation for music
  • Appreciation images
  • Appreciation film
  • Enjoyment of otherwise dull tasks
  • Enhanced creativity
  • Enhanced flow of ideas
  • Sensitivity to light
  • Pupil dilation
  • Open/closed-eye visuals
  • One sense blocked by other
  • Enhanced peripheral vision
  • Sound distortion
  • Auditory hallucinations
  • Yawning
  • Sedation or stimulation
  • Increased or decreased emotional sensitivity
  • Over-stimulation
  • significantly increased heart rate
  • Difficulty falling asleep
  • Sweating
  • Chills
  • Flushing
  • Muscle fatigue
  • Aching
  • Dizziness
  • Confusion

The consumer creates an additional layer to the real life. They start to think they are not in this world anymore. It starts to believe every object has an energy field around them. Change in perception of gravity has also been reported.

How long does DMT stay in your system?

The metabolizing rate of DMT is quicker compared to other drugs that people use. But different drug test on various parameters shows a variety of results. Also, the result will depend on the dose the drug is taken:

•    Urine tests: the presence of DMT is detected for a day or 24 hours. For the medication to pass the kidney and fully get out of the body.

•    Saliva tests: The presence is detected for up to five days. The route does not affect the lengths of the days. Smoking, snorting, or eating does not affect the time.

•    The longest time that the drug stays in our system is in the hair. Even after 90 days, the presence can be detected. Also, if the consumer is not a frequent user, the test will come positive for three months.

•    But the blood remains clean. Because the drug quickly gets metabolized by the liver. So no traceable amount is found in blood tests.

Is it legal to Buy 4-AcO-DMT Online

The legality of this drug is different in different countries.  Australia, the United States, the United Kingdom, Sweden, Italy all countries have declared 4-AcO-DMT to be illegal.  The manufacturing, getting the drug to the vendors, processing the compound for human consumption is against the law in the united states.

In the united kingdom, 4-AcO-DMT is listed as a “class a” substance as a misused drug. The “psychoactive substances” have addictive properties, and because this drug is used by the addicts, the general governing body prohibits selling this drug.

In Australia, the drug is prohibited, and the selling of this drug is strictly maintained. The same goes for New Zealand and some of the other European countries as well.

It is, however, an astonishing fact that many top world countries, including Canada, do not put any restrictions on selling the drug and perfectly legal.

4- aco= dmt

4-AcO-DMT vendor Online 

4-AcO-DMT is permitted in a few countries. Although there are not very vendors who sell this drug, there are a few listed online vendors who sell this drug.

Due to its high tolerance properties, and as this drug has high addictive properties without a prescription, this drug is not sold. You can buy 4-aco-dmt drugs from the following site.





Precaution of  4-AcO-DMT Use

There is several precautions one needs to take before taking this drug. First of all, the drug must be started at a low dose, and then the treatment will slowly increase. The correct dosage for the drug is something that must be maintained.

Easily a little overdose can create magic mushroom effects or hallucinations. The common side effect of 4-AcO-DMT is nausea and vomiting. So before taking this drug, it is wise to empty the stomach. The last meal should be at least 2 hours before taking the medication.

The taste of the powder drugs can be unpleasant, and this may cause stomach irritation. So it is wise to take any kind of juice with the medicine to suppress stomach irritation.

How flexible is 4-AcO-DMT tolerance?

4-AcO-DMT starts to develop tolerance in the consumer as soon as drug therapy begins. The tolerance takes around two to three years to return to its baseline. The consumer can also expect to get tolerance with another drug by crossing.

The Psilocin can create cross-tolerance with LSD, MDMA.2C-B, and other drugs that work on the 5-HT(serotonin) receptors.

4-AcO-DMT Drug Interaction 

4-AcO-DMT has high toxic effects. So this drug shouldn’t be taken with other medications such as tramadol, amphetamine stimulants, cocaine, lithium, etc. When 4-AcO-DMT is combined with psychedelics, they produce psychosis or seizures.

Similar effects are seen when it is combined with cannabis. Some of the consumers experience visual, sensory, and cognitive outcomes. MDMA, when interacted with 4-AcO-DMT in a higher dose, creates neurotoxicity. So a lower dosage is prescribed when administered with MDMA.

Ketamine also interacts with 4-AcO-DMT and creates an increased effect of visual, euphoria, and dissociation. But taking this must be made with precaution.

Some drugs are advised not to be taken with 4-AcO-DMT because the effect can be diminished. Alcohol is an example, and benzodiazepine also can lessen the impact of 4-AcO-DMT.

Treatment of 4-AcO-DMT tolerance 

Tolerance to 4-AcO-DMT is universal. Tolerance of a drug means the drug is not working in the individual’s body. When a drug gets used to the consumer’s body, the drug does not work anymore.

This is a problem.  4-AcO-DMT starts to create tolerance in the individual. So to avoid tolerance, the dose is needed to be measured. From a low dose, a little by little treatment is increased.

You can also read the article about 4-CMC drug by clicking here.


There is a little chance of getting an addiction to 4-AcO-DMT. But quickly, consumers can get tolerated. The chemical structure does not allow the consumer to become addicted. This mimics the effect of Psilocybin. Overdose can create overwhelming thoughts, and this can lead to life-ending actions. So logical medicine review is a must before buying such this drug.


4-AcO-DMT is a common drug used as a prodrug. The abuse of this drug is widespread among teenagers. They increase different feelings or activities, like thinking, suppresses ego. The Use of 4-AcO-DMT is a psychoactive drug.

But as this drug has hive dependence ability so the dose must be maintained.  4-AcO-DMT dosage is prescribed as a small dose and then increased slowly.


I'm Dr. Torrez Walker MD over 20 years in the pharmaceutical industry with experience in research Chemicals. Additional experience also covers Sox Testing, process improvements, and technical assessments. Consider responsible highly organized, with strong personal and communication skills; results and profit-oriented. Track record of success managing highly technical, very challenging and complex projects. SAP, Excel and Access Expert.

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